This page provides the full credits and references to Rhodiola Rosea: A Phytomedicinal Overview. We start with brief bios of each of the authors and then below that you will find the 92 specific references cited throughout this seminal piece of research on Rhodiola rosea.
Please note that Dr. Brown and Dr. Gerbarg published The Rhodiola Revolution in 2005, which contains further exploration of these studies and hopeful effects.
Richard P. Brown, M.D., is Associate Clinical Professor of Psychiatry at Columbia University College of Physicians and Surgeons in New York City. He received his M.D. in 1977 from Columbia University College of Physicians and Surgeons in New York. Dr. Brown completed his Residency in Psychiatry and a Fellowship in Psychobiology and Psychopharmacology at New York Hospital. Dr. Brown is the recipient of numerous awards, including a Mead-Johnson Neuropsychopharmacology Travel Fellowship, a Mallinckrodt Scholar award, and a Fellowship in Neurosciences and Brain Imaging from the Dana Foundation. He has had a longstanding interest in herbal and complementary medicine, especially as relevant to psychiatry. In 2000, he co-authored the book, Stop Depression Now, which presents a holistic approach to the treatment of depression, including SAM-e. Since 1999, Dr. Brown has taught a full day course on Herbs and Nutrients in Psychiatry at the annual meetings of the American Psychiatric Association. Dr. Brown has no financial interest in Rhodiola rosea.
Patricia L. Gerbarg, M.D., is Assistant Clinical Professor in Psychiatry at New York Medical Center. She graduated from Harvard Medical School in 1975 and completed her Psychiatry Residency at Beth Israel Hospital in Boston in 1979. She finished psychoanalytic training at the Boston Psychoanalytic Society and Institute in 1992 and has maintained a private psychiatric practice for 23 years. Dr. Gerbarg has taught and lectured on a range of topics in psychiatry and psychoanalysis. Over the past eight years she has been increasingly involved in research and writing about alternative and complementary medicine in psychiatry and has co-authored numerous articles and book chapters with Dr. Brown. Dr. Gerbarg has no financial interest in Rhodiola rosea.
Zakir Ramazanov, Ph.D., D.S., is Professor of Biochemistry at Las Palmas Technological Institute, Spain. In 1978 he received a bachelor’s degree with a double major in biochemistry and plant physiology from North Caucasian State University and in 1981 a Ph.D. in Plant Physiology and Biochemistry from the Soviet Academy of Sciences. He has served as Senior Scientist and Chief of the Department of Biotechnology at the Soviet Academy of Science and as Chairman of Algal Biotechnology Development. In 1991 he accepted a research fellowship at Louisiana State University. The recipient of numerous research grants, Dr. Ramazanov is known for his work in space biology, the cultivation of photosynthetic organisms in space stations, and the development of marine natural products from sea vegetables. He has published more than 140 scientific studies and co-authored two books: Arctic Root (Rhodiola rosea) — The powerful new Ginseng Alternative (1998) and Effective Natural Stress and Weight Management Using Rhodiola Rosea and Rhododendron Caucasicum (1999). Dr. Ramazanov was President and CEO of National Biosciences Corporation, Chester, NY.
Acknowledgement: The authors are grateful to Dr. Bertalan Galambosi from Agrifood Research Finland, Ecological Production, of Mikkeli, Finland, for providing the photographs of Rhodiola rosea.
1. Engler A. Syllabus der Pflanzenfamilien, Vol. 2. Berlin: Borntraeger; 1964: 199-200.
2. Saratikov AS, Krasnov EA. Rhodiola rosea is a valuable medicinal plant (Golden Root). Tomsk, Russia: Tomsk State University; 1987.
3. Mell CD. Dyes, tannins, perfumes, and medicines from Rhodiola rosea. Textile Colorist 1938; 60(715):483-4.
4. Linnaei C. Materia Medica. Liber I. De Plantis. Laurentii Salvii; 1749: 168.
5. Linnaeus CN. Ortabok. Stockholm: Almquist and Wiksell; 1725: 127.
6. Linnaeus C. Plants of Lapland. Uppsala, Sweden: 1754: 182-7.
7. Archiaterns R, Linnaeus C, Aspelin E. Flora Oeconomica. Upsala, Sweden: Lars Salvii; 1748: 399.
8. Tonning H. Chapter III Medica. Rariora Norvegiae. Upsaliae, Sweden:1768 p. 3-19.
9. Sandberg F, Bohlin L. Fytoterapi: växbaserade läkemedel (Remedies based on herbs). Stockholm: Hälsokostrådets förlag AB; 1993: 131.
10. Pharmacopée Françoise. Table alphabétique ravisée des drogues végétales. IX edition. Paris: 1974: A214.
11. Sandberg F. Phytomedicine from herbs. Spain: 1998: 223.
12. Mashkovskij MD. Doctor’s manual: medical drugs. 12 edition. Vol. 1. Moscow: Meditzina; 1976: 161-5.
13. Khaidaev Z, Menshikova TA. Medicinal Plants in Mongolian Medicine. Mongolia: Ulan-Bator Mongolia; 1978.
14. Magnusson B. Fägringar: Växter som berör oss (Beauty: herbs that touch us). Östersund, Sweden: Berntssons; 1992: 66-7.
15. Hoppe H. Drogen kunde, Band 1 Angiosperm 8. Walter de Gruyter; 1975: 986-7.
16. Nörr H. Phytochemical and pharmacological investigation of the adaptogens: Eleutherococcus senticocus, Ocimum sanctum, Codonopsis pilosula, Rhodiola crenulata Munchen: PhD. Dissertation, Faculty of Chemistry and Pharmacy, Ludwig Maximillians University. 1993.
17. Krylov GV. Herbs for Life. Novosibirsk: Academic Press; 1969: 264.
18. Darbinyan V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner H. Rhodiola rosea in stress induced fatigue—a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine 2000; 7(5):365-71.
19. Komorov VL editor. Genus 698. Rhodiola L. in: Flora of the USSR Volume IX, Rosales and Sarraceniales. Izdatel’stro Akad. Nauk SSSR. Moscova-Leningrad. 1939. Jerusalem, Israel: Israel Program for Scientific Translation; 1971: 20-36.
20. Rhodiola, Rosenwurz. in: Hegi H. Illustrierte Flora von Mitteleuropa. Zweite vollig neubearbeitete Auflage. Band IV/2, Liefering 2/3. 1963: 99-102.
21. Ohba H. A revision of the eastern Himalayan species of the subgenus Rhodiola of the genus Sedum. Flora of Eastern Himalaya, 3rd report. Ohashi H Ed. Tokyo: University of Tokyo Press; 1975: 283-362.
22. Saratikov AS, Krasnov EA. Chapter I: Chemical composition of Rhodiola rosea. in: Saratikov AS, Krasnov EA. Rhodiola rosea is a valuable medicinal plant (Golden Root). Tomsk, Russia: Tomsk State University; 1987 p. 3-39.
23. Kurkin VA, Zapesochnaya GG. Chemical composition and pharma- cological properties of Rhodiola rosea. Chemical and Pharmaceutical Journal (Moscow) 1986; 20(10):1231-44.
24. Saratikov AS. Golden Root (Rhodiola rosea). Russia: Tomsk; 1974.
25. Kurkin VA, Zapesochnaya GG. Chemical composition and pharmacological characteristics of Rhodiola rosea (review). Journal of Medicinal Plants, Russian Academy of Science, Moscow 1985; 1231-445.
26. Saratikov AS, Krasnov EA, Khnikina LA, Duvidson LM. Isolation and chemical analysis of individual biologically active constituents of Rhodiola rosea. Proceedings of the Siberian Academy of Sciences. Biology 1967; 1:54-60.
27. Russian National Pharmacopoeia. Pharmacopoeia article: PA 42-2126-83, liquid extract of Rhodiola rosea root and rhizome. Moscow: The Russian Federation Ministry of Health and Medical Industry; 1983.
28. Dubichev AG, Kurkin BA, Zapesochnaya GG, Vornotzov ED. Study of Rhodiola rosea root chemical composition using HPLC. Cemico-Parmaceutical Journal 1991; 2:188-93.
29. Ganzera M, Yayla Y, Khan IA. Analysis of the marker compounds of Rhodiola rosea L. (golden root) by reversed phase high performance liquid chromatography. Chem Pharm Bull (Tokyo) 2001; 49(4):465-7.
30. Zhang S, Wang J, Zhang H. Chemical constituents of Tibetan medicinal herb Rhodiola kirilowii (Reg.). Gansu Chung Kuo Chung Yao Tsa Chih 1991; 16(8):483, 512.
31. Wang S, Wang FP. Studies on the chemical components of Rhodiola crenulata. Yao Hsueh Hsueh Pao 1992; 27(2):117-20.
32. Wang S, You XT, Wang FP. HPLC determination of salidroside in the roots of Rhodiola genus plants. Yao Hsueh Hsueh Pao 1992; 27(11):849-52.
33. Brigel M, Beguin C. Isolation of rutoside, asparagines and a new glycoside, hydrolysable by emulsion, salidroside from Salix triandra L. C. G. Hebd. Séances Acad Sci 1926; 183:321-3.
34. Shi L, Ma Y, Cai Z. Quantitative determination of salidroside and specnuezhenide in the fruits of Ligustrum lucidum by high performance liquid chromatography. Biomed Chromatogr 1998; 12(1):27-30.
35. hieme H. On the identity of glucoside rhodioloside and salidroside. Pharmazie 1969; 24(2):118-9.
36. Thieme H, Walewska E, Winkler HJ. Isolation of salidroside from leaves of Rhododendron ponticum x catawbiense. Pharmazie 1969; 24(12):783.
37. Russian National Pharmacopoeia. Moscow: The Russian Federation Ministry of Health and Medical Industry; 1989.
38. Spasov AA, Wikman GK, Mandrikov VB, Mironova IA, Neumoin VV. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine 2000; 7(2):85-9.
39. Spasov AA, Mandrikov VB, Mironova IA. The effect of the preparation rodiosin on the psychophysiological and physical adaptation of students to an academic load. Eksp Klin Farmakol 2000; 63(1):76-8.
40. Furmanowa M, Oledzka H, Michalska M, Sokolnicka I, Radomska D. Chapter XXIII Rhodiola rosea L. (Roseroot): in vitro regeneration and the biological activity of roots. Biotechnology in agriculture and forestry, Vol. 33. Medicinal and aromatic plants VIII (ed. by YPS Bajaj). Berlin Heidelberg: Springer-Verlag; 1995 p. 412-26.
41. Saratikov AS, Krasnov EA. Chapter VII: Adaptogenic properties of Rhodiola rosea. in: Saratikov AS, Krasnov. Rhodiola rosea is a valuable medicinal plant (Golden Root). Tomsk, Russia: Tomsk State University; 1987 p. 194-215.
42. Petkov VD, Stancheva SL, Tocuschieva L, Petkov VV. Changes in brain biogenic monoamines induced by the nootropic drugs adafenoxate and meclofenoxate and by citicholine (experiments on rats). Gen Pharmacol 1990; 21(1):71-5.
43. Baranov VB First Deputy Director, IMBP. Experimental trials of herbal adaptogen effect on the quality of operation activity, mental and professional work capacity. Contract 93-11-615 Stage 2 Phase I. Moscow: Russian Federation Ministry of Health Institute of Medical and Biological Problems (IMBP); 1994.
44. Komar VV, Kit SM, Sischuk LV, Sischuk VM. Effect of Rhodiola on the human mental activity. Pharmaceutical J 1981; 36(4):62-4.
45. Stancheva SL, Mosharrof A. Effect of the extract of rhodiola rosea L. on the content of the brain biogenic monoamines. Medecine Physiologie Comptes Rendus De L’Académie Bulgare Des Sciences 1987; 40(6):85-7.
46. Lazarova MB, Petkov VD, Markovska VL, Petkov VV, Mosharrof A. Effects of meclofenoxate and Extr. Rhodiolae rosea L. on electroconvulsive shock-impaired learning and memory in rats. Methods Find Exp Clin Pharmacol 1986; 8(9):547-52.
47. Petkov VD, Yonkov D, Mosharoff A, Kambourova T, Alova L, Petkov VV, et al. Effects of alcohol aqueous extract from Rhodiola rosea L. roots on learning and memory. Acta Physiol Pharmacol Bulg 1986; 12(1):3-16.
48. Saratikov A, Mar’ina TF, Fisanova LL. Effect of golden root extract on processes of serotonin synthesis in CNS. Journal of Biological Sciences 1978; 6.
49. Mar’ina TF, Alekseeva LP. Effect of Rhodiola rosea extract on electroencephalograms in rabbit. in. Stimulants of the Central Nervous System. Tomsk, Russia: Tomsk State University Press; 1968: 22-6.
50. Mar’ina TF. Effect of Rhodiola rosea extract on bioelectrical activity of the cerebral cortex isolated to a different extent from the brain. in. Stimulants of the Central Nervous System. Tomsk, Russia: Tomsk State University Press; 1968: 27-31.
51. Brown RP, Gerbarg PG, Muskin PR. Alternative Therapies in Psychiatry. in: Tasman A, Lieberman J, Kay J, Editors. Psychiatry Second Edition [in press]. West Sussex, England: Wiley & Sons, Ltd.; 2002.
52. Lupien SJ, de Leon M, de Santi S, Convit A, Tarshish C, Nair NP, et al. Cortisol levels during human aging predict hippocampal atrophy and memory deficits. Nat Neurosci 1998; 1(1):69-73.
53. Furmanowa M, Skopinska-Rozewska E, Rogala E, Malgorzata H. Rhodiola rosea in vitro culture – phytochemical analysis and antioxidant action. Acta Societis Botanicorum Poloniae 1998; 76(1):69-73.
54. Durany N, Munch G, Michel T, Riederer P. Investigations on oxidative stress and therapeutical implications in dementia. Eur Arch Psychiatry Clin Neurosci 1999; 249 Suppl 3:68-73.
55. Joseph JA, Shukitt-Hale B, Denisova NA, Bielinski D, Martin A, McEwen JJ, et al. Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J Neurosci 1999; 19(18):8114-21.
56. Saratikov AS, Krasnov EA. Chapter VIII: Clinical studies of Rhodiola. in: Saratikov AS, Krasnov EA. Rhodiola rosea is a valuable medicinal plant (Golden Root). Tomsk, Russia: Tomsk State University; 1987 p. 216-27.
57. Krasik ED, Morozova ES, Petrova KP, Ragulina GA, Shemetova LA, Shuvaev VP. Therapy of asthenic conditions: clinical perspectives of application of Rhodiola rosea extract (golden root). In. Proceedings “Modern problems in psycho-pharmacology”. Kemerovo-city, Siber- ian Branch of Russian Academy of Sciences: Kemerovo Press Pub- lisher; 1970 p. 298-330.
58. Krasik ED, Petrova KP, Rogulina GA, Shemetova LYa, Shuvayeva. New data on the therapy of asthenic conditions (clinical prospects for the use of Rhodiola extract). Material for All-Russia Conf.: Urgent Problem in Psychopharmacology. 1970; 298-300.
59. Diagnostic and Statistical Manual of Mental Disorders, DSM-IV. Washington, DC: American Psychiatric Association; 1994.
60. Hickie I, Davenport T, Issakidis C, Andrews G. Neurasthenia: prevalence, disability, and health care characteristics in the Australian community. Br J Psychiatry 2002; 181:56-61.
61. Merikangas K, Angst J. Neurasthenia in longitudinal cohort study of young adults. Psychological Medicine 1994; 24(4):1013-24.
62. Lin TY. Neurasthenia revisited: its place in modern psychiatry. Psychiatric Annals 1992; 22(4):173-87.
63. Zheng YP, Lin KM, Takeuchi D, Kurasaki KS, Wang Y, Cheung F. An epidemiological study of neurasthenia in Chinese-Americans in Los Angeles. Comprehensive Psychiatry 1997; 38(5):249-59.
64. The International Classification of Diseases 10th Revision, ICD-10. Washington, DC: U. S. Department of Health and Human Services; 1992.
65. Zatova MI. Proceedings of Physiologists, Biochemists, and Pharmacologists of West Siberian Society. Pg 298-299. 1965.
66. Saratikov AS. Screening for natural central nervous system stimulants. in: Saratikov AS. Stimulants of the Central Nervous System. Vol. 1. Tomsk, Russia: Izdatelstvo Tomskogo Univ. (Tomsk State University); 1966 p. 3-23.
67. Brichenko VS, Kupriyanova IE, Skorokhova TF. The use of herbal adaptogens with tricyclic antidepressants in patients with psychogenic depression. Modern Problems of Pharmacology and Search for New Medicines. Tomsk: Tomsk University; 1986 p. 58-60.
68. Mattson MP, Pedersen WA, Duan W, Culmsee C, Camandola S. Cellular and molecular mechanisms underlying perturbed energy metabolism and neuronal degeneration in Alzheimer’s and Parkinson’s diseases. Ann N Y Acad Sci 1999; 893:154-75.
69. Saratikov AS, Krasnov EA. Chapter III: Stimulative properties of Rhodiola rosea. in: Saratikov AS, Krasnov EA. Rhodiola rosea is a valuable medicinal plant (Golden Root). Tomsk, Russia: Tomsk State University; 1987 p. 69-90.
70. Panossian A, Wikman G, Wagner H. Plant adaptogens. III. Earlier and more recent aspects and concepts on their mode of action. Phytomedicine 1999; 6(4):287-300.
71. Salnik BU. Effect of several stimulators on central nervous system energy metabolism during muscular workload [PhD thesis] Tomsk, Russia: Tomsk State University and Medical Institute. 1970.
72. Adamchuk LB. Effects of Rhodiola on the process of energetic recovery of rat under intense muscular workload [PhD thesis] Tomsk, Russia: Tomsk State University and Medical Institute. 1969.
73. Danbueva EA. Effect of stimulators of the central nervous system on lipid metabolism at different muscular workloads [PhD thesis] Tomsk, Russia: Tomsk State University and Medical Institute. 1968.
74. Revina TA. Effect of stimulators of the central nervous system on carbohydrate and high energy phosphorylated compound metabolism in the brain during intense muscular workload [PhD thesis] Tomsk, Russia: Tomsk State University and Medical Institute. 1969.
75. Brekhman II, Dardymov IV. New substances of plant origin which increase non-specific resistance. Ann Rev Pharmacol 1968; (9):419-30. 94(2):147-60.
76. Porsolt RD, Anton G, Blavet N, Jalfre M. Behavioral despair in rats: a new model sensitive to antidepressant treatments. Eur J Pharmacol 1978; 47(4):379-91.
77. Borsini F, Meli A. Is the forced swimming test a suitable model for revealing antidepressant activity? Psychopharmacology (Berl) 1988; nov EA. Rhodiola rosea is a valuable medicinal plant (Golden Root). Tomsk, Russia: Tomsk State University; 1987 p. 216-27.
78. Willner P. The validity of animal models of depression. Psychopharmacology (Berl) 1984; 83(1):1-16.
79. Boon-Niermeijer EK, van den Berg A, Wikman G, Wiegant FA. Phyto-adaptogens protect against environmental stress-induced death of embryos from the freshwater snail Lymnaea stagnalis. Phytomedicine 2000; 7(5):389-99.
80. Lishmanov IuB, Trifonova ZhV, Tsibin AN, Maslova LV, Dement’eva LA. Plasma beta-endorphin and stress hormones in stress and adaptation. Biull Eksp Biol Med 1987; 103(4):422-4.
81. Maslova LV, Kondrat’ev BIu, Maslov LN, Lishmanov IuB. The cardioprotective and antiadrenergic activity of an extract of Rhodiola rosea in stress. Eksp Klin Farmakol 1994; 57(6):61-3.
82. Gerasimova HD. Effect of Rhodiola rosea extract on ovarian functional activity. Proc. of Scientific Conference on Endocrinology and Gynecology. Sverdlovk, Russia. 1970; 46-8.
83. Saratikov AS, Krasnov EA. Chapter VI: The influence of Rhodiola on endocrine glands and the liver. in: Saratikov AS, Krasnov EA. Rhodiola rosea is a valuable medicinal plant (Golden Root). Tomsk, Russia: Tomsk State University; 1987 p. 180-93.
84. Maimeskulova LA, Maslov LN, Lishmanov IuB, Krasnov EA. [The participation of the mu-, delta- and kappa-opioid receptors in the realization of the anti-arrhythmia effect of Rhodiola rosea]. Eksp Klin Farmakol 1997; 60(1):38-9.
85. Baranov VB First Deputy Director, IMBP. The response of cardiovascular system to dosed physical load under the effect of herbal adaptogen. Contract 93-11-615 Phase I and Phase II. Moscow: Russian Federation Ministry of Health Institute of Medical and Biological Problems (IMBP); 1994.
86. Bol’shakova IV, Lozovskaia EL, Sapezhinskii II. Antioxidant properties of a series of extracts from medicinal plants. Biofizika 1997; 42(2):480-3.
87. Udintsev SN, Schakhov VP. Decrease of cyclophosphamide haematotoxicity by Rhodiola rosea root extract in mice with Ehrlich and Lewis transplantable tumors. Eur J Cancer 1991; 27(9):1182.
88. Borovskaya TG, Fomina TI, Iaremenko KV. A decrease in the toxic action of rubomycin on the small intestine of mice with a transplantable tumor through the use of a Rhodiola extract. Antiobiot Khimioter 1988; 33(8):615-7.
89. Udintsev SN, Krylova SG, Fomina TI. The enhancement of the efficacy of adriamycin by using hepatoprotectors of plant origin in metastases of Ehrlich’s adenocarcinoma to the liver in mice. Vopr Onkol 1992; 38(10):1217-22.
90. Udintsev SN, Shakhov VP. The role of humoral factors of regenerating liver in the development of experimental tumors and the effect of Rhodiola rosea extract on this process. Neoplasma 1991; 38(3):323-31.
91. Salikhova RA, Aleksandrova IV, Mazurik VK, Mikhailov VF, Ushenkova LN, Poroshenko GG. Effect of Rhodiola rosea on the yield of mutation alterations and DNA repair in bone marrow cells. Patol Fiziol Eksp Ter 1997; (4):22-4.
92. Bocharova OA, Matveev BP, Baryshnikov AIu, Figurin KM, Serebriakova RV, Bodrova NB. The effect of a Rhodiola rosea extract on the incidence of recurrences of a superficial bladder cancer (experimental clinical research). Urol Nefrol (Mosk) 1995; (2):46-7.
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